Principles of the Method

Clinical Appraisal

Calculation (Online and SW-Download)


SPINA (Structure Parameter Inference Approach), a method to calculate constant structure parameters of endocrine feedback control systems from hormone levels obtained in vivo, has been applied in a prototypical implementation for the evaluation of the thyroid function.

This application allows for calculating the thyroid's maximum secretion capacity and the sum activity of the peripheral 5'-deiodinase from the levels of TSH, FT4 and FT3 determined only once.

Please use the navigation bar in this window's left to get informed about SPINA's theory and practice and to perform calculations from your patients' data.


SPINA-GD predicts substitution dose with L-T4 according to trial.

SPINA Thyr 4.0.1 released.

Large study unveils existence of a TSH-T3 shunt in vivo.

Introduction | Principles of the method | Clinical appraisal | Calculate online and Download | Imprint

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© 1997-2015 J. W. Dietrich (Ideas, Conception and Development)
© 1997-2002 Klinikum der Universität München (Sponsoring)
© 2002-2005 Universitätsklinikum Ulm (Sponsoring)
© 2005-2015 Klinikum der RU Bochum (Sponsoring)
Last Change: Sat, Aug 22, 2015