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Clinical Appraisal
In a prototypical diagnostical study, thyrotropin (TSH) proved to be the most sensitive parameter for evaluation of the thyroid's function, whereas GT~ and GD~ showed a high specificity in diagnostics of several thyroid diseases (nodular goiter, toxic goiter, subacute thyroiditis, CAT and Graves' disease). This tendency was revealed both in the usage of conventional reference regions based on 95% tolerance intervals, and in the interpretation with ROC curves. [Dietrich et al. 1999, Dietrich 2002] In the same population we found significant correlations between thyroid volume as measured by ultrasonography and GT~ as well as between body mass index and GD~. Furthermore, we saw that in healthy volunteers receiving substitution therapy with iodine GT~ was weekly, but significantly higher than it was in persons without substitution therapy. A prospective study revealed significant correlation of creatinine clearance and GT~ in patients with chronic renal failure that were subjected to diet therapy [Rosolowska-Huszcz et al. 2005]. Currently, the AQUA-FONTIS Study, the largest proxpective study on non-thyroidal illness syndrome, is investigating the utility of SPINA for diagnosing and predicting the outcome of non-thyroidal illness syndrome in crtically ill patients. ReferencesDietrich, J. W., U. Mitzdorf, R. Weitkunat und C. R. Pickardt (1997). "The pituitary-thyroid feedback control: stability and oscillations in a new nonlinear model." Journal of Endocrinological Investigation 20 (Suppl. to no. 5): 100. Dietrich, J., M. Fischer, J. Jauch, E. Pantke, R. Gärtner und C. R. Pickardt (1999). "SPINA-THYR: A Novel Systems Theoretic Approach to Determine the Secretion Capacity of the Thyroid Gland." European Jounal of Internal Medicine 10, Suppl. 1 (5/1999): S34. Dietrich, J. W., A. Tesche, C. R. Pickardt und U. Mitzdorf (2002). Fractal Properties of the Thyrotropic Feedback Control: Implications of a Nonlinear Model Compared with Empirical Data. In: Cybernetics and Systems 2002. R. Trappl (Hrsg). Vienna. Dietrich JW, Tesche A, Pickardt CR, Mitzdorf U (2004). Thyrotropic Feedback Control: Evidence for an Additional Ultrashort Feedback Loop from Fractal Analysis. Cybernetics and Systems. 35(4):315-31. Rosolowska-Huszcz D, Kozlowska L, Rydzewski A (2005). Influence of low protein diet on nonthyroidal illness syndrome in chronic renal failure. Endocrine. 27(3):283-8 Dietrich, J. W. und B. O. Boehm (2006). Equilibrium behaviour of feedback-coupled physiological saturation kinetics. In: Cybernetics and Systems 2006. R. Trappl (Hrsg). Vienna, Austrian Society for Cybernetic Studies. 1: 269-74. Dietrich JW, Stachon A, Antic B, Klein HH, Hering S (2008). The AQUA-FONTIS Study: Protocol of a multidisciplinary, cross-sectional and prospective longitudinal study for developing standardized diagnostics and classification of non-thyroidal illness syndrome. BMC Endocr Disord. 13;8(1):13. |
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© 1997-2012 J. W. Dietrich (Ideas, Conception and Development) |
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