SPINA (Structure Parameter Inference Approach) is a method for calculating constant structure parameters of endocrine feedback control systems from serum or plasma hormone levels obtained in vivo.

A first implementation that has been applied to the in-vivo evaluation of thyroid function allows for calculating the thyroid's maximum secretory capacity (SPINA-GT) and the sum activity of peripheral 5'-deiodinases (SPINA-GD) from the levels of TSH, (F)T4 and (F)T3 that have been determined only once (SPINA Thyr). This method is increasingly used in experimental research and clinical trials.

Additional applications targeting other endocrine feedback loops are currently being developed or prepared, respectively.

Please find current clinical trials on SPINA at spina-studien.medical-cybernetics.de and software at spina.sf.net.


New clinical trial investigates SPINA-GD in hypothyroidism.

SPINA Thyr 3.4.2 released.

SPINA Thyr 3.4.1 available.

SPINA Thyr 3.4 to implement multiple new features.

SPINA Thyr 3.3.1 published.

Paper published on diagnostic evaluation of thyroid homeostasis.

SPINA Thyr 3.3 for Mac OS X, Linux and Windows.

SPINA covered in review paper on thyrotropic feedback control.

SPINA Thyr 3.2 for Mac OS X, Linux, Windows and Palm OS.

Abstract award of the North Rhine-Westphalian Society for Endocrinology and Diabetology for the AQUA FONTIS G study.

SimThyr 3.0 released.

SPINA Portal | SPINA Thyr | SPINA Carb | SPINA Cort | SPINA Calc | Imprint | AQUA FONTIS Network

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© 1997-2014 J. W. Dietrich (Ideas, Conception and Development)
© 1997-2002 Klinikum der Universität München (Sponsoring)
© 2002-2005 Universitätsklinikum Ulm (Sponsoring)
© 2005-2014 Klinikum der RU Bochum (Sponsoring)
Last Change: Thu, Jul 10, 2014