SPINA
SPINA
(Structure Parameter Inference Approach) is a method for
calculating constant structure parameters of endocrine
feedback control systems from hormone levels obtained in
vivo.
SPINA Carb is SPINA's second implementation. The
equations deliver biomarkers for insulin sensitivity and
pancreatic beta cell function. The methodology has been
validated in two cohorts.
Reference:
Dietrich JW, Dasgupta R, Anoop S, Jebasingh F, Kurian
ME, Inbakumari M, Boehm BO, Thomas N. SPINA Carb: a
simple mathematical model supporting fast in-vivo
estimation of insulin sensitivity and beta cell
function. Sci Rep. 2022 Oct 21;12(1):17659. doi
10.1038/s41598-022-22531-3. PMID 36271244;
PMCID
PMC9587026.
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