SPINA
SPINA
(Structure Parameter Inference Approach) is a method for
calculating constant structure parameters of endocrine
feedback control systems from hormone levels obtained in
vivo.
SPINA Carb is SPINA's second implementation. The
equations deliver biomarkers for insulin sensitivity (SPINA-GR) and
pancreatic beta cell function (SPINA-GBeta). Additionally, they provide
the basis for the calculation of a static disposition index (SPINA-DI) to estimate
the loop gain of the feedback control system.
The methodology has been validated in four cohorts. It could be
demonstrated in several clinical studies that it has higher validity, reliability
and diagnostic utility than alternative approaches.
References:
Dietrich JW, Dasgupta R, Anoop S, Jebasingh F, Kurian
ME, Inbakumari M, Boehm BO, Thomas N. SPINA Carb: a
simple mathematical model supporting fast in-vivo
estimation of insulin sensitivity and beta cell
function. Sci Rep. 2022 Oct 21;12(1):17659. doi
10.1038/s41598-022-22531-3. PMID 36271244;
PMCID
PMC9587026.
Dietrich JW, Abood A, Dasgupta R, Anoop S, Jebasingh FK, Spurgeon R,
Thomas N, Boehm BO. A novel simple disposition index (SPINA-DI) from
fasting insulin and glucose concentration as a robust measure of
carbohydrate homeostasis. J Diabetes. 2024 Jan 2.
doi 10.1111/1753-0407.13525. Epub ahead of print.
PMID 38169110.
Bansal V, Winkelmann BR, Dietrich JW, Boehm BO. Whole-exome sequencing in
familial type 2 diabetes identifies an atypical missense variant in the
RyR2 gene. Front Endocrinol (Lausanne). 2024 Feb 20;15:1258982. doi
10.3389/fendo.2024.1258982. PMID
38444585; PMCID PMC10913019.
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